Cas9 & gRNA Delivery

Find the best Cas9 and gRNA delivery options for your genome engineering application—choose from mRNA, lentivectors, protein, AAV, and more

With a wealth of options for delivering Cas9 and gRNA, SBI supports a full range of genome engineering applications. Deliver Cas9 and gRNA via mRNA, lentivector, or AAV, or use purified Cas9 protein, and then choose from our all-in-one systems that deliver Cas9 and gRNA on a single vector or two-component systems for separate introduction of Cas9 and gRNA.

Not sure which system to choose? Take a look at our table below, or contact technical support—we’re here to help you find the right product for your application and can provide expert experimental support.

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Cas9 & gRNA Delivery Products

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Cas9 SmartNuclease™ mRNA, Injection- and Transfection-ready

Move in vivo genome editing projects forward faster with injection- and transfection-ready Cas9 SmartNuclease mRNA
Size:
array(1) { [0]=> array(24) { ["attributes"]=> array(1) { ["attribute_size"]=> string(6) "20 µg" } ["availability_html"]=> string(0) "" ["backorders_allowed"]=> bool(false) ["dimensions"]=> array(3) { ["length"]=> string(0) "" ["width"]=> string(0) "" ["height"]=> string(0) "" } ["dimensions_html"]=> string(3) "N/A" ["display_price"]=> float(364) ["display_regular_price"]=> float(364) ["image"]=> array(18) { ["title"]=> string(20) "cas9-mrna-main-image" ["caption"]=> string(0) "" ["url"]=> string(85) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-mrna-main-image.jpg" ["alt"]=> string(0) "" ["src"]=> string(85) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-mrna-main-image.jpg" ["srcset"]=> bool(false) ["sizes"]=> string(31) "(max-width: 147px) 100vw, 147px" ["full_src"]=> string(85) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-mrna-main-image.jpg" ["full_src_w"]=> int(147) ["full_src_h"]=> int(109) ["gallery_thumbnail_src"]=> string(93) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-mrna-main-image-100x100.jpg" ["gallery_thumbnail_src_w"]=> int(100) ["gallery_thumbnail_src_h"]=> int(100) ["thumb_src"]=> string(85) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-mrna-main-image.jpg" ["thumb_src_w"]=> int(147) ["thumb_src_h"]=> int(109) ["src_w"]=> int(147) ["src_h"]=> int(109) } ["image_id"]=> string(4) "7466" ["is_downloadable"]=> bool(false) ["is_in_stock"]=> bool(true) ["is_purchasable"]=> bool(true) ["is_sold_individually"]=> string(2) "no" ["is_virtual"]=> bool(false) ["max_qty"]=> string(0) "" ["min_qty"]=> int(1) ["price_html"]=> string(142) "$364" ["sku"]=> string(9) "CAS500A-1" ["variation_description"]=> string(71) "

Transfection-ready Cas9 SmartNuclease mRNA (Eukaryotic version)

" ["variation_id"]=> int(63270) ["variation_is_active"]=> bool(true) ["variation_is_visible"]=> bool(true) ["weight"]=> string(0) "" ["weight_html"]=> string(3) "N/A" } }
(Cat. # CAS500A-1)

Cas9 SmartNickase™ mRNA, Injection- and Transfection-ready

Use injection- and transfection-ready Cas9 SmartNickase mRNA for in vivo genome editing projects where you need to limit off-target activity
Size:
array(1) { [0]=> array(24) { ["attributes"]=> array(1) { ["attribute_size"]=> string(6) "20 µg" } ["availability_html"]=> string(0) "" ["backorders_allowed"]=> bool(false) ["dimensions"]=> array(3) { ["length"]=> string(0) "" ["width"]=> string(0) "" ["height"]=> string(0) "" } ["dimensions_html"]=> string(3) "N/A" ["display_price"]=> float(364) ["display_regular_price"]=> float(364) ["image"]=> array(18) { ["title"]=> string(20) "cas9-nickase-protein" ["caption"]=> string(0) "" ["url"]=> string(85) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-nickase-protein.jpg" ["alt"]=> string(0) "" ["src"]=> string(93) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-nickase-protein-600x564.jpg" ["srcset"]=> string(190) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-nickase-protein-600x564.jpg 600w, https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-nickase-protein.jpg 800w" ["sizes"]=> string(31) "(max-width: 600px) 100vw, 600px" ["full_src"]=> string(85) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-nickase-protein.jpg" ["full_src_w"]=> int(800) ["full_src_h"]=> int(752) ["gallery_thumbnail_src"]=> string(93) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-nickase-protein-100x100.jpg" ["gallery_thumbnail_src_w"]=> int(100) ["gallery_thumbnail_src_h"]=> int(100) ["thumb_src"]=> string(93) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-nickase-protein-300x300.jpg" ["thumb_src_w"]=> int(300) ["thumb_src_h"]=> int(300) ["src_w"]=> int(600) ["src_h"]=> int(564) } ["image_id"]=> string(5) "17632" ["is_downloadable"]=> bool(false) ["is_in_stock"]=> bool(true) ["is_purchasable"]=> bool(true) ["is_sold_individually"]=> string(2) "no" ["is_virtual"]=> bool(false) ["max_qty"]=> string(0) "" ["min_qty"]=> int(1) ["price_html"]=> string(142) "$364" ["sku"]=> string(9) "CAS504A-1" ["variation_description"]=> string(85) "

Transfection-ready Cas9 SmartNickase mRNA (Eukaryotic Nickase mutant version)

" ["variation_id"]=> int(63273) ["variation_is_active"]=> bool(true) ["variation_is_visible"]=> bool(true) ["weight"]=> string(0) "" ["weight_html"]=> string(3) "N/A" } }
(Cat. # CAS504A-1)

hspCas9-T2A-GFP SmartNuclease™ mRNA, Injection- and Transfection-ready

When you want to be sure - verify that your Cas9 mRNA has been successfully transfected into target cells with Cas9 SmartNuclease mRNA that also delivers GFP
Size:
array(1) { [0]=> array(24) { ["attributes"]=> array(1) { ["attribute_size"]=> string(6) "10 µg" } ["availability_html"]=> string(0) "" ["backorders_allowed"]=> bool(false) ["dimensions"]=> array(3) { ["length"]=> string(0) "" ["width"]=> string(0) "" ["height"]=> string(0) "" } ["dimensions_html"]=> string(3) "N/A" ["display_price"]=> float(322) ["display_regular_price"]=> float(322) ["image"]=> array(18) { ["title"]=> string(13) "cas9-gfp-mrna" ["caption"]=> string(0) "" ["url"]=> string(78) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-gfp-mrna.png" ["alt"]=> string(0) "" ["src"]=> string(86) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-gfp-mrna-600x411.png" ["srcset"]=> string(176) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-gfp-mrna-600x411.png 600w, https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-gfp-mrna.png 938w" ["sizes"]=> string(31) "(max-width: 600px) 100vw, 600px" ["full_src"]=> string(78) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-gfp-mrna.png" ["full_src_w"]=> int(938) ["full_src_h"]=> int(642) ["gallery_thumbnail_src"]=> string(86) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-gfp-mrna-100x100.png" ["gallery_thumbnail_src_w"]=> int(100) ["gallery_thumbnail_src_h"]=> int(100) ["thumb_src"]=> string(86) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-gfp-mrna-300x300.png" ["thumb_src_w"]=> int(300) ["thumb_src_h"]=> int(300) ["src_w"]=> int(600) ["src_h"]=> int(411) } ["image_id"]=> string(4) "7405" ["is_downloadable"]=> bool(false) ["is_in_stock"]=> bool(true) ["is_purchasable"]=> bool(true) ["is_sold_individually"]=> string(2) "no" ["is_virtual"]=> bool(false) ["max_qty"]=> string(0) "" ["min_qty"]=> int(1) ["price_html"]=> string(142) "$322" ["sku"]=> string(9) "CAS530G-1" ["variation_description"]=> string(93) "

Transfection-ready hspCas9-T2A-GFP SmartNuclease mRNA (wildtype Cas9 with GFP marker)

" ["variation_id"]=> int(63283) ["variation_is_active"]=> bool(true) ["variation_is_visible"]=> bool(true) ["weight"]=> string(0) "" ["weight_html"]=> string(3) "N/A" } }
(Cat. # CAS530G-1)

hspCas9-T2A-RFP SmartNuclease™ mRNA, Injection- and Transfection-ready

When you want to be sure - verify that your Cas9 mRNA has been successfully transfected into target cells with a Cas9 SmartNuclease mRNA that also delivers RFP
Size:
array(1) { [0]=> array(24) { ["attributes"]=> array(1) { ["attribute_size"]=> string(6) "10 µg" } ["availability_html"]=> string(0) "" ["backorders_allowed"]=> bool(false) ["dimensions"]=> array(3) { ["length"]=> string(0) "" ["width"]=> string(0) "" ["height"]=> string(0) "" } ["dimensions_html"]=> string(3) "N/A" ["display_price"]=> float(322) ["display_regular_price"]=> float(322) ["image"]=> array(18) { ["title"]=> string(13) "cas9-rfp-mrna" ["caption"]=> string(0) "" ["url"]=> string(78) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-rfp-mrna.png" ["alt"]=> string(0) "" ["src"]=> string(86) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-rfp-mrna-600x413.png" ["srcset"]=> string(176) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-rfp-mrna-600x413.png 600w, https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-rfp-mrna.png 939w" ["sizes"]=> string(31) "(max-width: 600px) 100vw, 600px" ["full_src"]=> string(78) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-rfp-mrna.png" ["full_src_w"]=> int(939) ["full_src_h"]=> int(647) ["gallery_thumbnail_src"]=> string(86) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-rfp-mrna-100x100.png" ["gallery_thumbnail_src_w"]=> int(100) ["gallery_thumbnail_src_h"]=> int(100) ["thumb_src"]=> string(86) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-rfp-mrna-300x300.png" ["thumb_src_w"]=> int(300) ["thumb_src_h"]=> int(300) ["src_w"]=> int(600) ["src_h"]=> int(413) } ["image_id"]=> string(4) "7282" ["is_downloadable"]=> bool(false) ["is_in_stock"]=> bool(true) ["is_purchasable"]=> bool(true) ["is_sold_individually"]=> string(2) "no" ["is_virtual"]=> bool(false) ["max_qty"]=> string(0) "" ["min_qty"]=> int(1) ["price_html"]=> string(142) "$322" ["sku"]=> string(9) "CAS531R-1" ["variation_description"]=> string(93) "

Transfection-ready hspCas9-T2A-RFP SmartNuclease mRNA (wildtype Cas9 with RFP marker)

" ["variation_id"]=> int(63285) ["variation_is_active"]=> bool(true) ["variation_is_visible"]=> bool(true) ["weight"]=> string(0) "" ["weight_html"]=> string(3) "N/A" } }
(Cat. # CAS531R-1)

hspCas9-T2A-GFP SmartNickase™ mRNA, Transfection-ready

When you want to be sure—verify that your Cas9 SmartNickase mRNA has been successfully transfected into target cells with an mRNA that also delivers GFP
Size:
array(1) { [0]=> array(24) { ["attributes"]=> array(1) { ["attribute_size"]=> string(6) "10 µg" } ["availability_html"]=> string(0) "" ["backorders_allowed"]=> bool(false) ["dimensions"]=> array(3) { ["length"]=> string(0) "" ["width"]=> string(0) "" ["height"]=> string(0) "" } ["dimensions_html"]=> string(3) "N/A" ["display_price"]=> float(322) ["display_regular_price"]=> float(322) ["image"]=> array(18) { ["title"]=> string(20) "cas9-nickase-protein" ["caption"]=> string(0) "" ["url"]=> string(85) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-nickase-protein.jpg" ["alt"]=> string(0) "" ["src"]=> string(93) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-nickase-protein-600x564.jpg" ["srcset"]=> string(190) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-nickase-protein-600x564.jpg 600w, https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-nickase-protein.jpg 800w" ["sizes"]=> string(31) "(max-width: 600px) 100vw, 600px" ["full_src"]=> string(85) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-nickase-protein.jpg" ["full_src_w"]=> int(800) ["full_src_h"]=> int(752) ["gallery_thumbnail_src"]=> string(93) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-nickase-protein-100x100.jpg" ["gallery_thumbnail_src_w"]=> int(100) ["gallery_thumbnail_src_h"]=> int(100) ["thumb_src"]=> string(93) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-nickase-protein-300x300.jpg" ["thumb_src_w"]=> int(300) ["thumb_src_h"]=> int(300) ["src_w"]=> int(600) ["src_h"]=> int(564) } ["image_id"]=> string(5) "17632" ["is_downloadable"]=> bool(false) ["is_in_stock"]=> bool(true) ["is_purchasable"]=> bool(true) ["is_sold_individually"]=> string(2) "no" ["is_virtual"]=> bool(false) ["max_qty"]=> string(0) "" ["min_qty"]=> int(1) ["price_html"]=> string(142) "$322" ["sku"]=> string(9) "CAS534G-1" ["variation_description"]=> string(106) "

Transfection-ready hspCas9-nickase-T2A-GFP SmartNickase mRNA (Cas9 Nickase mutant with GFP marker)

" ["variation_id"]=> int(63287) ["variation_is_active"]=> bool(true) ["variation_is_visible"]=> bool(true) ["weight"]=> string(0) "" ["weight_html"]=> string(3) "N/A" } }
(Cat. # CAS534G-1)

hspCas9-T2A-RFP SmartNickase™ mRNA, Transfection-ready

When you want to be sure—verify that your Cas9 SmartNickase mRNA has been successfully transfected into target cells with an mRNA that also delivers RFP
Size:
array(1) { [0]=> array(24) { ["attributes"]=> array(1) { ["attribute_size"]=> string(6) "10 µg" } ["availability_html"]=> string(0) "" ["backorders_allowed"]=> bool(false) ["dimensions"]=> array(3) { ["length"]=> string(0) "" ["width"]=> string(0) "" ["height"]=> string(0) "" } ["dimensions_html"]=> string(3) "N/A" ["display_price"]=> float(322) ["display_regular_price"]=> float(322) ["image"]=> array(18) { ["title"]=> string(23) "all-in-one-cas9-plasmid" ["caption"]=> string(0) "" ["url"]=> string(88) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/all-in-one-cas9-plasmid.png" ["alt"]=> string(0) "" ["src"]=> string(88) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/all-in-one-cas9-plasmid.png" ["srcset"]=> string(299) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/all-in-one-cas9-plasmid.png 345w, https://systembio.com/wp-content/uploads/crispr-cas9-systems/all-in-one-cas9-plasmid-300x300.png 300w, https://systembio.com/wp-content/uploads/crispr-cas9-systems/all-in-one-cas9-plasmid-100x100.png 100w" ["sizes"]=> string(31) "(max-width: 345px) 100vw, 345px" ["full_src"]=> string(88) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/all-in-one-cas9-plasmid.png" ["full_src_w"]=> int(345) ["full_src_h"]=> int(345) ["gallery_thumbnail_src"]=> string(96) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/all-in-one-cas9-plasmid-100x100.png" ["gallery_thumbnail_src_w"]=> int(100) ["gallery_thumbnail_src_h"]=> int(100) ["thumb_src"]=> string(96) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/all-in-one-cas9-plasmid-300x300.png" ["thumb_src_w"]=> int(300) ["thumb_src_h"]=> int(300) ["src_w"]=> int(345) ["src_h"]=> int(345) } ["image_id"]=> string(5) "20497" ["is_downloadable"]=> bool(false) ["is_in_stock"]=> bool(true) ["is_purchasable"]=> bool(true) ["is_sold_individually"]=> string(2) "no" ["is_virtual"]=> bool(false) ["max_qty"]=> string(0) "" ["min_qty"]=> int(1) ["price_html"]=> string(142) "$322" ["sku"]=> string(9) "CAS535R-1" ["variation_description"]=> string(106) "

Transfection-ready hspCas9-nickase-T2A-RFP SmartNickase mRNA (Cas9 Nickase mutant with RFP marker)

" ["variation_id"]=> int(63289) ["variation_is_active"]=> bool(true) ["variation_is_visible"]=> bool(true) ["weight"]=> string(0) "" ["weight_html"]=> string(3) "N/A" } }
(Cat. # CAS535R-1)

Cas9 SmartNuclease™ AAVS1 gRNA, Transfection-ready

Easily target Cas9 activity to the AAVS1 Safe Harbor Site with this pre-built gRNA specific for AAVS1
Size:
array(1) { [0]=> array(24) { ["attributes"]=> array(1) { ["attribute_size"]=> string(6) "10 µg" } ["availability_html"]=> string(0) "" ["backorders_allowed"]=> bool(false) ["dimensions"]=> array(3) { ["length"]=> string(0) "" ["width"]=> string(0) "" ["height"]=> string(0) "" } ["dimensions_html"]=> string(3) "N/A" ["display_price"]=> float(264) ["display_regular_price"]=> float(264) ["image"]=> array(18) { ["title"]=> string(29) "cas9-smartnuclease-aavs1-grna" ["caption"]=> string(0) "" ["url"]=> string(94) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-smartnuclease-aavs1-grna.png" ["alt"]=> string(0) "" ["src"]=> string(102) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-smartnuclease-aavs1-grna-600x446.png" ["srcset"]=> string(209) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-smartnuclease-aavs1-grna-600x446.png 600w, https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-smartnuclease-aavs1-grna.png 1145w" ["sizes"]=> string(31) "(max-width: 600px) 100vw, 600px" ["full_src"]=> string(94) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-smartnuclease-aavs1-grna.png" ["full_src_w"]=> int(1145) ["full_src_h"]=> int(852) ["gallery_thumbnail_src"]=> string(102) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-smartnuclease-aavs1-grna-100x100.png" ["gallery_thumbnail_src_w"]=> int(100) ["gallery_thumbnail_src_h"]=> int(100) ["thumb_src"]=> string(102) "https://systembio.com/wp-content/uploads/crispr-cas9-systems/cas9-smartnuclease-aavs1-grna-300x300.png" ["thumb_src_w"]=> int(300) ["thumb_src_h"]=> int(300) ["src_w"]=> int(600) ["src_h"]=> int(446) } ["image_id"]=> string(4) "7345" ["is_downloadable"]=> bool(false) ["is_in_stock"]=> bool(true) ["is_purchasable"]=> bool(true) ["is_sold_individually"]=> string(2) "no" ["is_virtual"]=> bool(false) ["max_qty"]=> string(0) "" ["min_qty"]=> int(1) ["price_html"]=> string(142) "$264" ["sku"]=> string(9) "CAS520A-1" ["variation_description"]=> string(56) "

Transfection-ready Cas9 SmartNuclease AAVS1 gRNA

" ["variation_id"]=> int(63281) ["variation_is_active"]=> bool(true) ["variation_is_visible"]=> bool(true) ["weight"]=> string(0) "" ["weight_html"]=> string(3) "N/A" } }
(Cat. # CAS520A-1)

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