Putting exosomes to work: Creating stable cell lines that produce miRNA-delivering exosomes
Expanding on our powerful XMIR and AXMIR technologies, SBI developed the XMIRXpress Lentivector System, which enables the creation of stable cell lines that produce exosomes carrying a specific miRNA. Just as with XMIR and AXMIR, you can take advantage of normal cellular processes to package a specific miRNA into exosomes, and then use those exosomes to deliver that miRNA to target cells. Choose from one of our pre-built, ready-to-transfect XMIRXpress Lentivectors (see list below). If you don’t see the miRNA you’re interested in, simply contact us at firstname.lastname@example.org and we’ll design and synthesize the custom XMIR for you, or build your own using the XMIRXpress Cloning Lentivector.
All XMIRXpress Lentivectors feature an EF1a-GFP-Puro selection cassette and a downstream H1 promoter expressing the XMIR + XMotif cassette.
- Flexible—turn the cell line of your choice into a factory that produces miRNA-packed exosomes
- Powerful—great for a range of applications, including:
- Modulating expression of miRNA-targets in recipient cells
- Developing exosome-delivered miRNA-based therapies