Integrase-based Systems

When you want non-viral expression from low or single-copy integration events, and/or have a large insert size, choose one of SBI’s integrase-based systems

Choose one of SBI’s integrase-based gene expression systems when you want a non-viral system that integrates at low- or single-copy. Both our PhiC31 and PinPoint Systems support unlimited insert sizes, and come in a variety of promoter and reporter combinations.

The PhiC31 Integrase System

  • Frequently used for gene therapy development and related applications
  • Non-viral transgene delivery
  • Single-step process
  • Single-copy integration
  • Preferential integration at active sites
  • Delivery of inserts with no size constraints
  • Easy generation of cell lines

The PinPoint Targeted Integration System

  • Isogenic cell line creation
  • Reliable and efficient cell line generation and retargeting
  • Non-viral transgene delivery
  • Two-step process
  • High-efficiency, site-specific, single-copy integration
  • Delivery of inserts with no size constraints
  • Compatible with high-throughput workflows

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Integrase-based Systems

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PinPoint-FC attP Placement Vector

Easily place the PinPoint attP site into a target genome with the PhiC31 Integrase Expression Plasmid and this PinPoint attP Placement Vector
Size:10 µg (Cat. # PIN300A-1)

PinPoint-FC System for Platform Cell Line Generation & Retargeting

Get all the plasmids you need for PinPoint Targeted Integration using the PhiC31 Integrase to place the PinPoint attP site into the target genome
Size:1 Kit (Cat. # PIN300A-KIT)

PinPoint-FC 293T Platform Cell Line for Targeted Gene Insertion (PinPoint attP already placed)

Jump start your PinPoint cell line creation with this 293T cell line that already has a single PinPoint attP site inserted into the genome
Size:>2x10^5 Cells (Cat. # PIN320A-1)

PinPoint-FC 293T Platform Kit for Targeted Gene Insertion (PinPoint attP already placed)

Get your PinPoint projects going fast with this kit that includes 293T cells that already have a PinPoint attP site and all the necessary PinPoint plasmids
Size:1 Kit (Cat. # PIN320A-KIT)

PinPoint-FC Murine iPSC Platform Cell Line for Targeted Gene Insertion (PinPoint attP already placed)

Jump start your PinPoint cell line creation with this Murine iPS cell line that already has a single PinPoint attP site inserted into the genome
Size:>2x10^5 Cells (Cat. # PIN340iPS-1)

PinPoint-FC Murine iPSC Platform Kit for Targeted Gene Insertion (PinPoint attP already placed)

Get your PinPoint projects moving with this kit that includes Murine iPS cells that already have a PinPoint attP site and all the necessary PinPoint plasmids
Size:1 Kit (Cat. # PIN340iPS-KIT)

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