Targeted Protein Degradation

Quickly knock-down protein activity using Piranha Targeted Protein Degradation System - robust, targeted protein degradation.

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While studying protein function in vivo often involves knocking down expression using siRNA or knocking out the gene via CRISPR/Cas9, these approaches are indirect and often imperfect. siRNA can reduce or eliminate protein expression, but if the protein turn-over rate is slow then it can take days to see a reduction in function. Simply knocking out the gene coding for the protein-of-interest limits the type of studies you can do and is incompatible with essential genes. To give researchers another faster option, SBI developed the Piranha Targeted Protein Degradation System.

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Piranha™ Targeted Protein Degradation Electroporation-ready mRNA

Quickly knock-down protein activity using Piranha Electroporation-ready mRNA – robust, targeted protein degradation.

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Piranha™ Electroporation-Ready mRNA

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Piranha™ Electroporation-ready RFP-tagged mRNA

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Piranha™ Electroporation-ready GFP-tagged mRNA

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10 µg (Cat. # PTPD500A-1), 10 µg (Cat. # PTPD510A-1), 10 µg (Cat. # PTPD520A-1)

Piranha™ Targeted Protein Degradation HEK293T GFP/Puromycin Stable Cell Line

Ready-to-go cell line for targeted protein degradation screens—just add antibodies—the Piranha system is constitutively expressed in HEK293T cells.

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Piranha™ HEK293T GFP/Puromycin Stable Cell Line

" ["variation_id"]=> int(88114) ["variation_is_active"]=> bool(true) ["variation_is_visible"]=> bool(true) ["weight"]=> string(0) "" ["weight_html"]=> string(3) "N/A" } }

>1x10^6 cell/vial (Cat. # PTPD600A-1)

pCDH-CMV-Piranha™-EF1-GFP-T2A-Puro Pre-packaged Lentivirus

Create your own targeted protein degradation cell line using SBI’s exclusive ready-to-transduce Piranha lentivirus marked with GFP and puromycin.

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pCDH-CMV-Piranha™-EF1a-GFP-T2A-Puro Lentivirus

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>1 x 10^6 IFUs (Cat. # PTPD513VA-1)

pCDH-EF1a-Piranha™-T2A-Puro Pre-packaged Lentivirus

Use ready-to-transduce Piranha lentivirus marked with puro and expressed from the EF1α promoter to build your own targeted protein degradation cell line.

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pCDH-EF1a-Piranha™-T2A-Puro Lentivirus

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>1 x 10^6 IFUs (Cat. # PTPD527VA-1)

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