Targeted Protein Degradation

Quickly knock-down protein activity using Piranha Targeted Protein Degradation System - robust, targeted protein degradation.

While studying protein function in vivo often involves knocking down expression using siRNA or knocking out the gene via CRISPR/Cas9, these approaches are indirect and often imperfect. siRNA can reduce or eliminate protein expression, but if the protein turn-over rate is slow then it can take days to see a reduction in function. Simply knocking out the gene coding for the protein-of-interest limits the type of studies you can do and is incompatible with essential genes. To give researchers another faster option, SBI developed the Piranha Targeted Protein Degradation System.

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Targeted Protein Degradation Products

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pCDH-CMV-Piranha™-EF1-GFP-T2A-Puro Pre-packaged Lentivirus

Create your own targeted protein degradation cell line using SBI’s exclusive ready-to-transduce Piranha lentivirus marked with GFP and puromycin.
Size:
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pCDH-CMV-Piranha™-EF1a-GFP-T2A-Puro Lentivirus

" ["variation_id"]=> int(88116) ["variation_is_active"]=> bool(true) ["variation_is_visible"]=> bool(true) ["weight"]=> string(0) "" ["weight_html"]=> string(3) "N/A" } }
>1 x 10^6 IFUs (Cat. # PTPD513VA-1)

pCDH-EF1a-Piranha™-T2A-Puro Pre-packaged Lentivirus

Use ready-to-transduce Piranha lentivirus marked with puro and expressed from the EF1α promoter to build your own targeted protein degradation cell line.
Size:
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pCDH-EF1a-Piranha™-T2A-Puro Lentivirus

" ["variation_id"]=> int(88118) ["variation_is_active"]=> bool(true) ["variation_is_visible"]=> bool(true) ["weight"]=> string(0) "" ["weight_html"]=> string(3) "N/A" } }
>1 x 10^6 IFUs (Cat. # PTPD527VA-1)

Piranha™ Targeted Protein Degradation Electroporation-ready mRNA

Quickly knock-down protein activity using Piranha Electroporation-ready mRNA – robust, targeted protein degradation.
Sizes:
array(3) { [0]=> array(24) { ["attributes"]=> array(1) { ["attribute_pa_size"]=> string(10) "10-%c2%b5g" } ["availability_html"]=> string(0) "" ["backorders_allowed"]=> bool(false) ["dimensions"]=> array(3) { ["length"]=> string(0) "" ["width"]=> string(0) "" ["height"]=> string(0) "" } ["dimensions_html"]=> string(3) "N/A" ["display_price"]=> float(295) ["display_regular_price"]=> float(295) ["image"]=> array(18) { ["title"]=> string(49) "main-Piranha-targeted-protein-degradation-mRNA-01" ["caption"]=> string(0) "" ["url"]=> string(94) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01.png" ["alt"]=> string(0) "" ["src"]=> string(94) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01.png" ["srcset"]=> string(426) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01.png 500w, https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01-150x150.png 150w, https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01-300x300.png 300w, https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01-100x100.png 100w" ["sizes"]=> string(31) "(max-width: 500px) 100vw, 500px" ["full_src"]=> string(94) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01.png" ["full_src_w"]=> int(500) ["full_src_h"]=> int(500) ["gallery_thumbnail_src"]=> string(102) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01-100x100.png" ["gallery_thumbnail_src_w"]=> int(100) ["gallery_thumbnail_src_h"]=> int(100) ["thumb_src"]=> string(102) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01-300x300.png" ["thumb_src_w"]=> int(300) ["thumb_src_h"]=> int(300) ["src_w"]=> int(500) ["src_h"]=> int(500) } ["image_id"]=> string(5) "88144" ["is_downloadable"]=> bool(false) ["is_in_stock"]=> bool(true) ["is_purchasable"]=> bool(true) ["is_sold_individually"]=> string(2) "no" ["is_virtual"]=> bool(false) ["max_qty"]=> string(0) "" ["min_qty"]=> int(1) ["price_html"]=> string(142) "$295" ["sku"]=> string(10) "PTPD500A-1" ["variation_description"]=> string(49) "

Piranha™ Electroporation-Ready mRNA

" ["variation_id"]=> int(88107) ["variation_is_active"]=> bool(true) ["variation_is_visible"]=> bool(true) ["weight"]=> string(0) "" ["weight_html"]=> string(3) "N/A" } [1]=> array(24) { ["attributes"]=> array(1) { ["attribute_pa_size"]=> string(10) "10-%c2%b5g" } ["availability_html"]=> string(0) "" ["backorders_allowed"]=> bool(false) ["dimensions"]=> array(3) { ["length"]=> string(0) "" ["width"]=> string(0) "" ["height"]=> string(0) "" } ["dimensions_html"]=> string(3) "N/A" ["display_price"]=> float(325) ["display_regular_price"]=> float(325) ["image"]=> array(18) { ["title"]=> string(49) "main-Piranha-targeted-protein-degradation-mRNA-01" ["caption"]=> string(0) "" ["url"]=> string(94) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01.png" ["alt"]=> string(0) "" ["src"]=> string(94) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01.png" ["srcset"]=> string(426) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01.png 500w, https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01-150x150.png 150w, https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01-300x300.png 300w, https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01-100x100.png 100w" ["sizes"]=> string(31) "(max-width: 500px) 100vw, 500px" ["full_src"]=> string(94) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01.png" ["full_src_w"]=> int(500) ["full_src_h"]=> int(500) ["gallery_thumbnail_src"]=> string(102) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01-100x100.png" ["gallery_thumbnail_src_w"]=> int(100) ["gallery_thumbnail_src_h"]=> int(100) ["thumb_src"]=> string(102) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01-300x300.png" ["thumb_src_w"]=> int(300) ["thumb_src_h"]=> int(300) ["src_w"]=> int(500) ["src_h"]=> int(500) } ["image_id"]=> string(5) "88144" ["is_downloadable"]=> bool(false) ["is_in_stock"]=> bool(true) ["is_purchasable"]=> bool(true) ["is_sold_individually"]=> string(2) "no" ["is_virtual"]=> bool(false) ["max_qty"]=> string(0) "" ["min_qty"]=> int(1) ["price_html"]=> string(142) "$325" ["sku"]=> string(10) "PTPD510A-1" ["variation_description"]=> string(60) "

Piranha™ Electroporation-ready RFP-tagged mRNA

" ["variation_id"]=> int(88196) ["variation_is_active"]=> bool(true) ["variation_is_visible"]=> bool(true) ["weight"]=> string(0) "" ["weight_html"]=> string(3) "N/A" } [2]=> array(24) { ["attributes"]=> array(1) { ["attribute_pa_size"]=> string(10) "10-%c2%b5g" } ["availability_html"]=> string(0) "" ["backorders_allowed"]=> bool(false) ["dimensions"]=> array(3) { ["length"]=> string(0) "" ["width"]=> string(0) "" ["height"]=> string(0) "" } ["dimensions_html"]=> string(3) "N/A" ["display_price"]=> float(325) ["display_regular_price"]=> float(325) ["image"]=> array(18) { ["title"]=> string(49) "main-Piranha-targeted-protein-degradation-mRNA-01" ["caption"]=> string(0) "" ["url"]=> string(94) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01.png" ["alt"]=> string(0) "" ["src"]=> string(94) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01.png" ["srcset"]=> string(426) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01.png 500w, https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01-150x150.png 150w, https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01-300x300.png 300w, https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01-100x100.png 100w" ["sizes"]=> string(31) "(max-width: 500px) 100vw, 500px" ["full_src"]=> string(94) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01.png" ["full_src_w"]=> int(500) ["full_src_h"]=> int(500) ["gallery_thumbnail_src"]=> string(102) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01-100x100.png" ["gallery_thumbnail_src_w"]=> int(100) ["gallery_thumbnail_src_h"]=> int(100) ["thumb_src"]=> string(102) "https://systembio.com/wp-content/uploads/main-Piranha-targeted-protein-degradation-mRNA-01-300x300.png" ["thumb_src_w"]=> int(300) ["thumb_src_h"]=> int(300) ["src_w"]=> int(500) ["src_h"]=> int(500) } ["image_id"]=> string(5) "88144" ["is_downloadable"]=> bool(false) ["is_in_stock"]=> bool(true) ["is_purchasable"]=> bool(true) ["is_sold_individually"]=> string(2) "no" ["is_virtual"]=> bool(false) ["max_qty"]=> string(0) "" ["min_qty"]=> int(1) ["price_html"]=> string(142) "$325" ["sku"]=> string(10) "PTPD520A-1" ["variation_description"]=> string(61) "

Piranha™ Electroporation-ready GFP-tagged mRNA

" ["variation_id"]=> int(88197) ["variation_is_active"]=> bool(true) ["variation_is_visible"]=> bool(true) ["weight"]=> string(0) "" ["weight_html"]=> string(3) "N/A" } }
10 µg (Cat. # PTPD500A-1), 10 µg (Cat. # PTPD510A-1), 10 µg (Cat. # PTPD520A-1)

Piranha™ Targeted Protein Degradation HEK293T GFP/Puromycin Stable Cell Line

Ready-to-go cell line for targeted protein degradation screens—just add antibodies—the Piranha system is constitutively expressed in HEK293T cells.
Size:
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Piranha™ HEK293T GFP/Puromycin Stable Cell Line

" ["variation_id"]=> int(88114) ["variation_is_active"]=> bool(true) ["variation_is_visible"]=> bool(true) ["weight"]=> string(0) "" ["weight_html"]=> string(3) "N/A" } }
>1x10^6 cell/vial (Cat. # PTPD600A-1)

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